Two prisoners escape through the swamp land in Everglades and the search party is attacked by a giant mutant eel and is considered missing. The Animal Control agent Delmar Coates is searching a missing dog with his ex-wife Sheriff Ruth Gainey-Coates and he discovers the remains of the animal. Meanwhile members of a canoe club organize an expedition through the swamp. When Sheriff Ruth organizes a manhunt to capture the criminals, Delmar informs that his former friend, Dr. Soren Abramson, who is chasing the eel with a group of college students, is the responsible for mutant species. Sheriff Ruth organizes two teams to hunt the prisoners and the eel.