The Substance (2024) Horror Drama Sci-Fi

Rated R | Threatrical Sep 20, 2024 (US) | Genres Horror, Drama, Sci-Fi | Runtime 2h 21m
The Substance (2024) Horror Drama Sci-Fi Poster

The Substance Plot Synopsis:


Synopsis / Plot Summary: A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.

Tagline: If you follow the instructions, what could go wrong?

Demi Moore gives a career best performance as Elisabeth Sparkle, a former A-lister past her prime and suddenly fired from her fitness TV show by repellent studio head Harvey (Dennis Quaid).

She is then drawn to the opportunity presented by a mysterious new drug: THE SUBSTANCE. All it takes is one injection and she is reborn – temporarily – as the gorgeous, twentysomething Sue (Margaret Qualley).

The only rule? Time needs to be split: exactly one week in one body, then one week in the other. No exceptions. A perfect balance. What could go wrong?

Deliriously entertaining and ruthlessly satirical, Coralie Fargeat’s Cannes sensation turns toxic beauty culture inside out with a be-careful-what-you-wish-for fable for the ages. Explosive, provocative and twisted, THE SUBSTANCE marks the arrival of a thrillingly visionary filmmaker.

More: Most Anticipated Horror Movies Coming Soon in 2026-2027!

Official Trailer

  • The Substance Official Trailer

The Substance Movie Information:

Type: Movie
Year: 2024 (more 2024 movies)
MPAA Rating: R
Runtime: 141 minutes /
Genres:  Horror, Drama, Sci-Fi
Horror Subgenres:  Body Horror, Extreme
Directors: Coralie Fargeat
Stars: Margaret Qualley, Dennis Quaid, Demi Moore, Hugo Diego Garcia, Joseph Balderrama … (cast list)
Release Date: Theatrical Release Date Sep 20, 2024
Box Office: $17,584,795
Oscars: 1
Awards: 143
Nominations: 279
Language: English
Country: United Kingdom, France
Release Dates: Movie Release Dates / The Substance Release Dates In Theaters: Sep 20, 2024
Producers: Tim Bevan, Coralie Fargeat, Eric Fellner, Jon Finn, Alexandra Loewy, Claire O'Neill, Nicolas Royer
Musicians: Raffertie
Cinematographers: Benjamin Kracun
Trending in Movies:

Forgive Us All (2025), Whistle (2025), Hell House LLC: Lineage (2025), 28 Years Later: The Bone… (2026), 28 Years Later (2025), We Bury the Dead (2024), Bring Her Back (2025), Strange Harvest: Occult Murder… (2024), Parvulos (2024), and ZombieCON Vol. 1 (2024)

Check Out the Best Horror Movies of 2026 You Must See!

Check out more movies that start with T and movies from 2024. Also, here are some more sci-fi movies that start with T.

More: Must See New Horror Movies in 2026!

Browse Horror Movies 2026 / New Horror Movies Coming Soon

1 Users added The Substance to their faves list.


Source: IMDB, Metacritic, Rotten Tomatoes, HellHorror.com fans like you!